The complexity and multidimensionality of urban problems and issues, along with the rapid growth of technology and globalization of production patterns, have increased. The instability of conditions and the possibility of various futures have made decision-making and planning regarding urban issues more difficult. In such circumstances, sustainable urban regeneration with a futures studies approach can be a solution to the problems of inefficient urban textures, especially historical textures. Therefore, any issues and topics related to the regeneration of inefficient urban fabrics must be examined with a multidimensional perspective and a combination of various factors. Accordingly, the present research aims to identify and analyze the key drivers affecting the regeneration of the historical fabric of the city of Arak. This study is applied in terms of objective and, based on futures studies methods, analytical and exploratory in nature. For data collection, a mixed method based on interviews and the Delphi technique, as well as documentary review and field study, has been used. The statistical population consists of 25 expert urban planners selected through snowball sampling, whose data were processed using Structural Cross-Impact Analysis in MICMAC software. This paper uses the Delphi method and cross-impact analysis, along with MICMAC software, to identify key drivers. The results obtained after inputting the scores into MICMAC showed that 29 factors were recognized as the main and driving factors in the development of the historical fabric regeneration of Arak city. Among these, factors such as integrated management of the historical fabric, facilitation by the government, and the establishment of specific regeneration laws jointly ranked first and second in terms of influence and are considered key drivers for the regeneration of Arak’s historical fabric.