With the spread of modernity and the process of individualism and social fragmentation, the level of social isolation has always been a sensitive issue for the qualitative assessment of the human environment, especially cities.This research is applied in terms of purpose and descriptive-analytical in nature and based on the future research method. The main goal of this research is to identify the main effective factors in the city of Ardabil in increasing social isolation. In this research, to identify the key variables effective in increasing social isolation, after studying upstream documents, the two-stage Delphi method and the use of MicMac software were used. The data analyzed included 33 variables as primary variables effective in social isolation. Using MicMac software, it was determined that 9 variables were identified as drivers of increasing social isolation.The variables of unbalanced distribution of urban services, unemployment and economic pressure were the 3 main variables with the highest impact. The results of the present study show that the pattern of formation and intensification of social isolation in the city of Ardabil can be observed in a multidimensional and structural framework; in such a way that a set of economic, spatial, managerial, and social factors affect the reduction of social interactions and the increase of urban isolation, causing inequality in citizens' access to social interaction opportunities, and this leads to a decrease in social presence and a decline in urban vitality in some neighborhoods.However, if urban policies move towards strengthening spatial justice, developing public spaces, promoting social security, and creating local economic opportunities, the future path of the city of Ardabil can be changed towards increasing social interactions and strengthening social capital.